A group of researchers from Xiamen University and Zhejiang University have developed a novel humanised mouse model to study liver cirrhosis formation induced by hepatitis B virus.
The earlier studies showed that mesenchymal stem cells from human bone marrow (hBMSCs) have the potential to differentiate into hepatocyte-like cells in vitro and continue to maintain essential hepatocyte functions in vivo after being transplanted into host mouse livers.
research team transplanted human bone marrow into mice. The mice show robust differentiation and proliferation of functional human hepatocytes and multiple immune cells.
The studies show that the new humanised mouse model recapitulates the liver cirrhosis induced by human HBV infection, providing opportunities for better understanding the immune pathophysiology of HBV and testing promising antiviral therapies in vivo.The research paper got published in British Journal of Gut.